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Updated: Jul 15, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Clinicopathologic correlations of stage IE/IIE primary thyroid diffuse large B-cell lymphoma
N Niitsu1, M Okamoto, N Nakamura
1Division of Hematology, Department of Internal Medicine, Saitama Medical University, Saitama, Japan. nniitsu@saitama-med.ac.jp
Summary
Localized thyroid diffuse large B-cell lymphoma (DLBCL) shows a good prognosis, particularly the germinal center B-cell (GCB) type. This study analyzed 32 patients, revealing high survival rates and treatment responses.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Thyroid diffuse large B-cell lymphoma (DLBCL) is a rare extranodal non-Hodgkin lymphoma.
- Understanding its clinicopathological features and prognosis is crucial for patient management.
Purpose of the Study:
- To investigate the clinicopathological characteristics and prognoses of localized stage thyroid DLBCL.
- To evaluate treatment outcomes and survival rates in this patient cohort.
Main Methods:
- Retrospective analysis of 32 patients diagnosed with stage I/IIE thyroid DLBCL.
- Immunophenotyping (CD20, CD5, CD10, CD23, BCL2, BCL6) and cytogenetic analysis were performed.
- Treatment modalities included chemotherapy alone or chemotherapy followed by radiotherapy.
Main Results:
- The median age of patients was 66 years, with a male/female ratio of 10/22.
- CD20 positivity was observed in 31/32 patients. Abnormal karyotypes were present in 12 cases.
- A complete response rate of 94% was achieved. The 5-year progression-free survival was 84%, and overall survival was 90%.
Conclusions:
- Localized thyroid DLBCL generally has a favorable prognosis.
- The germinal center B-cell (GCB) subtype demonstrated a significantly better prognosis compared to the non-GCB type.
- Thyroid DLBCL is a heterogeneous disease requiring tailored therapeutic approaches.
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