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Updated: Jul 15, 2026
An In Vitro Model to Study the Effect of 5-Aminolevulinic Acid-mediated Photodynamic Therapy on Staphylococcus aureus Biofilm
Published on: April 16, 2018
[Experimental studies on treatment of HSV infections with photodynamic therapy using 5-aminolevulinic acid]
Ji-ning Tao1, Shu-min Duan, Jun Li
1Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd, Shanghai 201203, China.
Objective:
To investigate in vitro and in vivo anti-human herpes simplex virus effects of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA).
Methods:
Guinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT.
Results:
The in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related.
Conclusion:
ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections.
