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[Application of UV similarity in quality control of Chinese medical injection]
Qing-hua Meng1, Wei-bo Wang, Yu-zhu Hu
1Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China. mqhxz@btamail.net.cn
Objective:
To propose an algorithm of the similarity between UV-spectra for controlling the quality of Chinese medical injection.
Method:
The similarity is calculated base on the data of two UV-spectrum curves, thus the sample quality is evaluated according to the average value of the similarity of the UV-spectra between sample with each of standard samples; the proposed algorithm of the similarity is compared with cosine of vectorial angle and relative coefficient; the proposed method for quality evaluation of traditional Chinese injection is discussed with the method according to the chromatographic fingerprint similarity.
Result:
The calculated similarity with the proposed method can be sensitive to show the difference between UV-spectra. This proposed method for quality evaluation was applied for assessing quality of 14 batches of Xiangdan injection and the results well coincident with sample quality.
Conclusion:
The proposed method can be used to evaluate the quality of the Chinese medical injection according to the similarity of two UV-spectrum curves.
