[Antibiotics at term. Questions about five severe allergic accidents]

Area of Science:

• Obstetrics and Gynecology
• Neonatal Medicine
• Pharmacology

Context:

• Antibiotic administration in late pregnancy for Group B Streptococcal (GBS) infections.
• Observed severe maternal allergic reactions in five distinct cases.
• Focus on infections occurring near or at term.

Purpose:

• To report and discuss severe maternal allergic reactions linked to antibiotic use for GBS sepsis.
• To analyze treatment strategies for severe maternal allergic reactions.
• To question and evaluate the appropriate use of antibiotics in this obstetric context.

Summary:

• Five cases of severe maternal allergic reactions were observed following antibiotic administration.
• Antibiotics were given near or at term to treat or prevent Early Onset Neonatal Group B Streptococcal Sepsis.
• The study discusses management of these severe allergic reactions and questions antibiotic necessity.

Impact:

• Raises critical questions about the risk-benefit balance of antibiotic use in late pregnancy.
• Informs clinical practice regarding antibiotic stewardship in obstetrics.
• Highlights the potential for severe adverse drug reactions in pregnant patients.