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Mouse behavioral mutants have neuroimaging abnormalities.

Brian J Nieman1, Jason P Lerch, Nicholas A Bock

  • 1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada.

Human Brain Mapping
|April 18, 2007
PubMed
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Neuroimaging reveals that 87% of mice with behavioral deficits show anatomical brain abnormalities. This highlights neuroimaging as a sensitive tool for detecting neurological disease in mouse models.

Area of Science:

  • Neuroscience
  • Genetics
  • Medical Imaging

Background:

  • Neurological diseases manifest as impaired cognitive, memory, or motor functions.
  • Noninvasive neuroimaging is crucial for diagnosing and staging neurological diseases in humans.
  • Neuroimaging is increasingly used in research laboratories to study animal models of neurological disease.

Purpose of the Study:

  • To determine the prevalence of neuroimaging abnormalities in mice with neurological symptoms.
  • To assess the utility of neuroimaging as a sensitive marker for neurological disease in mouse models.

Main Methods:

  • A meta-analysis was conducted on studies of behavioral mouse mutants from the researchers' laboratory.
  • Fifteen different mutant genotypes were evaluated using neuroimaging techniques.

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Main Results:

  • Thirteen out of fifteen mutant genotypes (87%) exhibited abnormal neuroimaging findings.
  • A high prevalence of neuroanatomical alterations was observed in mice with behavioral deficits.

Conclusions:

  • Disease processes affecting behavior in mice frequently alter neuroanatomy.
  • Neuroimaging is a highly sensitive method for detecting neurological disease in mice exhibiting abnormal behavior.