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Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease
Published on: May 10, 2024
Inhaled corticosteroids for stable chronic obstructive pulmonary disease
I A Yang1, K M Fong, E H A Sim
1Prince Charles Hospital and University of Queensland, Department of Thoracic Medicine and School of Medicine, Rode Rd, Chermside, Brisbane, Queensland, Australia, 4032. Ian_Yang@health.qld.gov.au
The Cochrane Database of Systematic Reviews
|April 20, 2007
Summary
Long-term use of inhaled corticosteroids (ICS) in COPD offers benefits like reduced exacerbations and improved quality of life, but increases risks of oral thrush and hoarseness. The long-term safety profile remains uncertain.
Area of Science:
- Pulmonary Medicine
- Pharmacology
Background:
- The efficacy of inhaled corticosteroids (ICS) in managing chronic obstructive pulmonary disease (COPD) remains debated, with conflicting findings from recent meta-analyses.
- International guidelines advocate for the selective use of ICS in COPD management.
Purpose of the Study:
- To systematically evaluate the effectiveness of regular inhaled corticosteroid use in patients with stable COPD.
Main Methods:
- A comprehensive literature search of the Cochrane Airways Group specialized register was conducted up to October 2006.
- Included were randomized trials comparing any ICS dose/type against placebo in COPD patients, with lung function as the primary outcome.
- Data on mortality, exacerbations, quality of life, symptoms, and safety were also analyzed.
Main Results:
- Long-term ICS use did not significantly slow the decline in lung function (FEV1) but reduced exacerbation rates and the decline in quality of life.
- A statistically significant increase in the risk of oropharyngeal candidiasis and hoarseness was observed with ICS use.
- No significant effect on mortality was found, and long-term studies showed minimal impact on bone health.
Conclusions:
- The benefits of ICS in COPD, including reduced exacerbations and improved quality of life, should be weighed against increased local side effects.
- The long-term safety profile and risks associated with inhaled corticosteroid therapy in COPD require further investigation.
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