Epidemiologic study of analgesic abuse: mortality study in 7275 working women (1968-1987)

In a prospective, longitudinal investigation over a period of 20 years in 7275 working women 30 to 49 years old, we examined the effect of the ingestion of analgesics on cause-specific mortality. Evidence of intake of phenacetin and salicylate containing analgesics was obtained at a urine screening in 1967 and was shown to relate to intake between 1968 to 1978. Life table analysis of the effect of phenacetin intake on overall mortality showed significant differences between the groups of women with intake (N = 613) versus no intake (N = 4175): for total [relative risk (RR) = 2.1, P less than 0.001], urorenal (RR = 24.4, P less than 0.001), cardiovascular (RR = 4.5, P less than 0.001), and cancer mortality (RR = 1.9, P less than 0.001). No significant effects on overall or cause-specific mortality were found for salicylate intake. These results make a causal relationship between the amount of analgesic containing phenacetin consumed and the risk of death from urorenal disease likely. Furthermore, the data show an elevated risk for cardiovascular disease and cancer for phenacetin intake. No such relationships are demonstrable for the use of salicylate.