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Updated: Jul 15, 2026
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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Delayed developmental language milestones in children with Duchenne's muscular dystrophy
Shana E Cyrulnik1, Robert J Fee, Darryl C De Vivo
1Graduate Center of the City University of New York, New York, USA.
The Journal of Pediatrics
|April 25, 2007
Summary
Children with Duchenne
Area of Science:
- Pediatric Neurology
- Developmental Pediatrics
- Genetics
Background:
- Duchenne's muscular dystrophy (DMD) is a progressive genetic disorder primarily affecting motor development.
- Developmental milestones, including motor and language acquisition, are crucial indicators of child development.
- Previous research has focused on motor delays in DMD, with less attention to early language development and cognitive links.
Purpose of the Study:
- To document the achievement of developmental milestones in children with DMD.
- To compare milestone attainment between children with DMD and their unaffected siblings.
- To investigate the association between early developmental delays and later cognitive functioning in DMD.
Main Methods:
- Retrospective parental reports were used to assess the acquisition of 10 common developmental milestones.
- The study included 130 children with DMD and 59 unaffected siblings.
- Cognitive functioning was assessed using standardized tests in children with DMD.
Main Results:
- Children with DMD experienced more frequent delays in both language and motor milestones compared to siblings.
- Early delays in language (late talkers) and motor (late walkers) milestones were observed in DMD.
- Children with DMD who had early delays performed significantly worse on cognitive function tests.
Conclusions:
- DMD is associated with delays in both motor and language milestone acquisition.
- Early language and motor delays in DMD are linked to later cognitive impairments.
- These findings highlight the importance of early developmental assessments in children with DMD.
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