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Related Concept Videos

Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

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Related Experiment Video

Updated: Jul 15, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

The hearing system under thyroid hypofunction.

S Khechinaschvili1, D Metreveli, N Svanidze

  • 1Otorhinolaryngological Clinic, State Medical University, Tbilisi, Georgia.

Georgian Medical News
|May 3, 2007
PubMed
Summary

Hypothyroidism frequently causes sensorineural hearing loss and central auditory processing disorders. Hormonal therapy shows limited effectiveness in improving these auditory issues in patients with thyroid hypofunction.

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Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

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Published on: February 9, 2024

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Published on: April 11, 2025

Area of Science:

  • Otolaryngology
  • Endocrinology
  • Audiology

Background:

  • Hypothyroidism can affect various bodily systems, including the auditory system.
  • Understanding the auditory impact of thyroid hypofunction is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate auditory system function in patients with thyroid hypofunction.
  • To assess peripheral and central hearing disorders associated with hypothyroidism.

Main Methods:

  • Pure tone audiometry (PTA) to determine hearing thresholds.
  • Brief tone audiometry (BTA) to evaluate temporal summation.
  • Evoked otoacoustic emissions (EOAEs), auditory brainstem responses (ABRs), and acoustic reflexes (ARs) for objective assessments.

Main Results:

  • Sensorineural hearing loss detected in 74.0% of patients via PTA.
  • Disturbances in cochlear receptor temporal summation found in 26.0% using BTA.
  • ABRs and ARs indicated central hearing disorders in 30.0% and 26.0% respectively.
  • EOAEs and BTA identified abnormalities even when PTA thresholds were normal.

Conclusions:

  • Hypothyroidism is associated with significant peripheral and central auditory impairments.
  • Hormonal therapy demonstrates minimal efficacy in ameliorating these auditory deficits.
  • Comprehensive audiological evaluation is recommended for patients with thyroid hypofunction.