Related Experiment Video
Updated: Jul 15, 2026
09:24
Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins
Published on: June 14, 2016
Upper airway mucin gene expression: a review.
Mahmoud S Ali1, Jeffrey P Pearson
1Epithelial Group, Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, United Kingdom. msamomar@yahoo.co.uk
The Laryngoscope
|May 3, 2007
Summary
Upper airway mucin expression, particularly MUC5AC, MUC5B, and MUC2, varies widely in chronic diseases. Further research with larger sample sizes is needed to clarify these patterns and develop new therapies.
Area of Science:
- Biochemistry
- Genetics
- Otorhinolaryngology
Background:
- Mucus gel properties are determined by mucins, encoded by mucin genes.
- Sixteen of the 20 known mucin genes are found in the airways, influencing mucus characteristics.
Purpose of the Study:
- To review current knowledge on upper airway mucin expression in health and disease.
- To investigate and compare upper airway mucin gene expression patterns.
Main Methods:
- Conducted a Medline search to gather existing data on upper airway mucin expression.
- Analyzed and compared upper airway mucin gene expression data with other studies.
Main Results:
- MUC5AC, MUC5B, and MUC2 are the primary gel-forming mucins in the airway.
- Chronic upper airway diseases show a broad and inconsistent range of mucin expression.
Conclusions:
- Variability in mucin expression is linked to diverse anatomic, histologic, physiologic, and pathologic factors.
- Larger studies are crucial for defining precise mucin expression patterns and understanding regulatory mechanisms for potential therapeutic development.
Related Concept Videos
01:16Drugs Used in Upper Respiratory Disorders: Overview
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:29Microbiota of the Respiratory Tract
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining. Bicarbonate,...