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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Ocular involvement in children with localised scleroderma: a multi-centre study.
Maria Elisabetta Zannin1, Giorgia Martini, Balu H Athreya
1Department of Pediatrics, Via Giustiniani 3, 35128 Padova, Italy. ezannin@pediatria.unipd.it
The British Journal of Ophthalmology
|May 4, 2007
Summary
Ocular abnormalities affect 3.2% of juvenile localized scleroderma patients, particularly those with facial scleroderma en coup de sabre. Early ophthalmic monitoring is crucial, especially with neurological involvement.
Area of Science:
- Ophthalmology
- Pediatrics
- Dermatology
Background:
- Limited data exists on ocular involvement in localized scleroderma (LS), primarily from adult case reports.
- This study focuses on the frequency and characteristics of ocular involvement in a large cohort of children with juvenile LS (JLS).
Purpose of the Study:
- To determine the prevalence and specific features of ocular involvement in children diagnosed with juvenile localized scleroderma.
- To identify subtypes of JLS associated with higher risks of ocular complications.
- To highlight the association between ocular and other systemic (particularly neurological) manifestations in JLS.
Main Methods:
- Analysis of data from a large, multi-center, multinational study involving children with JLS.
- Collection and statistical analysis of specific information regarding ocular involvement in the JLS cohort.
Main Results:
- Ocular involvement was identified in 3.2% (24/750) of JLS patients.
- Scleroderma en coup de sabre (ECDS) facial subtype was most common (66.7%) among affected children.
- Common ocular findings included adnexal abnormalities (41.7%), anterior segment inflammation (29.2%), and CNS-related issues (12.5%).
Conclusions:
- Ocular abnormalities are a significant concern in JLS, particularly in the ECDS subtype.
- Ocular involvement in JLS frequently co-occurs with other systemic conditions, notably neurological involvement.
- Routine ophthalmic screening is recommended for all JLS patients, with mandatory monitoring for those with facial lesions or CNS involvement.
