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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Video

Updated: Jul 15, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

HDL cholesterol: physiology, pathophysiology, and management.

Jeffrey J Link1, Anand Rohatgi, James A de Lemos

  • 1Department of Internal Medicine, Parkland Memorial Hospital affiliated with the University of Texas, Southwestern Medical Center, Dallas, Texas 75390-9047, USA.

Current Problems in Cardiology
|May 8, 2007
PubMed
Summary

High-density lipoprotein cholesterol (HDL) is a key factor in coronary heart disease (CHD) risk. While HDL is a promising therapeutic target, effective treatments for low HDL remain limited, with emerging therapies showing potential.

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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

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Last Updated: Jul 15, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

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Published on: November 17, 2018

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Pharmacology

Background:

  • Epidemiological studies consistently identify high-density lipoprotein cholesterol (HDL) as an independent risk factor for coronary heart disease (CHD).
  • HDL is recognized as a significant emerging therapeutic target for cardiovascular risk reduction, potentially comparable to statins.
  • The anti-atherogenic effects of HDL are complex, influenced by metabolism, kinetics, subclasses, and genetic factors, which standard plasma measurements may not fully represent.

Purpose of the Study:

  • To review the role of HDL cholesterol in cardiovascular disease.
  • To explore HDL as a therapeutic target for coronary heart disease.
  • To discuss current limitations and future directions in pharmacologic therapy for low HDL levels.

Main Methods:

  • Literature review of epidemiological studies on HDL and CHD.
  • Analysis of HDL metabolism, kinetics, and functionality.
  • Evaluation of current and emerging pharmacologic therapies for HDL modulation.

Main Results:

  • Low HDL levels are a significant risk factor for CHD.
  • Existing therapies offer modest improvements in serum HDL levels.
  • Emerging therapeutic strategies hold promise for more substantial impacts on HDL and CHD risk.

Conclusions:

  • HDL cholesterol remains a critical target for cardiovascular disease prevention.
  • Further research and clinical evidence are needed to establish formal HDL treatment guidelines.
  • Novel pharmacologic interventions are anticipated to play a greater role in managing HDL levels and reducing CHD risk.