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Updated: Jul 15, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
[HPV vaccines. Prophylactic vaccines from virus-like particles]
1Abteilung für Immundermatologie und Infektiöse Hautkrankheiten, Klinik für Dermatologie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Osterreich. reinhard.kirnbauer@meduniwien.ac.at
New prophylactic vaccines against human papillomavirus (HPV) use virus-like particles and are safe. HPV vaccination is 100% effective in preventing persistent infections and related genital dysplasia.
Area of Science:
- Oncology
- Virology
- Immunology
Context:
- Human papillomavirus (HPV) is a common viral infection linked to various cancers.
- Prophylactic vaccines are crucial for preventing HPV-related diseases.
Purpose:
- To evaluate the safety and efficacy of new prophylactic HPV vaccines.
- To assess the role of L1 major capsid protein in vaccine development.
Summary:
- The novel prophylactic HPV vaccines are composed of virus-like particles derived from the L1 major capsid protein.
- These vaccines are safe and well-tolerated, with no viral DNA, as demonstrated in extensive clinical trials.
- Vaccination shows 100% efficacy in preventing HPV-type-specific persistent infections and subsequent genital dysplasias.
Impact:
- Significant reduction in HPV-related infections and precancerous lesions.
- Potential for widespread prevention of HPV-associated cancers.
- Highlights the success of L1-based virus-like particle vaccines in public health.
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