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Childhood invasive pneumococcal disease: a hospital-based study from Malaysia

Li Han Lim1, Way Seah Lee, Navaratnam Parasakthi

  • 1Department of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.

Journal of Paediatrics and Child Health
|May 11, 2007
PubMed

Insights

Invasive pneumococcal disease (IPD) significantly impacts young Malaysian children, often caused by penicillin-non-susceptible Streptococcus pneumoniae strains. Further serotype data is crucial for effective immunization strategies in Malaysia.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • A new conjugate vaccine for Streptococcus pneumoniae has been introduced in Malaysia.
  • Information on invasive pneumococcal disease (IPD) in Malaysian children is limited.
  • This study reviews childhood IPD cases at a Malaysian tertiary care center.

Purpose of the Study:

  • To describe the characteristics and outcomes of childhood IPD in Malaysia.
  • To identify the prevalence of penicillin-non-susceptible Streptococcus pneumoniae strains.
  • To inform the potential impact of pneumococcal immunization in Malaysia.

Main Methods:

  • Retrospective chart review of children under 14 years with IPD.
  • Study period: May 1999 to August 2004 (5 years, 4 months).
  • Cases identified from the Department of Medical Microbiology records at University of Malaya Medical Centre.

Main Results:

  • 50 children diagnosed with IPD; median age 1.1 years, 76% under 2 years.
  • Common infections: pneumonia, meningitis, bacteraemia; 24% experienced complications like seizures and hearing loss.
  • No deaths reported; 62% of isolates were penicillin-non-susceptible.

Conclusions:

  • IPD causes significant morbidity in young Malaysian children.
  • Penicillin-non-susceptible strains are prevalent.
  • Serotype information is needed to evaluate the effectiveness of current and future immunization programs against Streptococcus pneumoniae in Malaysia.
Abstract

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