Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epilepsy surgery.

John S Duncan1

  • 1National Hospital for Neurology and Neurosurgery, Queen Square, London, j.duncan@ion.ucl.ac.uk

Clinical Medicine (London, England)
|May 12, 2007
PubMed
Summary
This summary is machine-generated.

For refractory epilepsy, neurosurgery offers a 60-70% chance of remission when antiepileptic drugs fail. Specialized evaluation is crucial for identifying suitable candidates for surgical intervention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

InnerEye-HS: a disease-agnostic clinical tool for hippocampal segmentation.

Brain communications·2026
Same author

Postmortem MRI reveals distinct structural features in sudden unexpected death in epilepsy.

Epilepsia open·2026
Same author

Bilateral ictal eye closure in focal epileptic seizures: SEEG retrospective observational assessment from a tertiary epilepsy center.

Epileptic disorders : international epilepsy journal with videotape·2026
Same author

Dual mechanism of anti-seizure medications in controlling seizure activity.

Brain communications·2026
Same author

Abnormal functional connectivity patterns in temporal lobe epilepsy-An international ENIGMA-epilepsy study.

Epilepsia open·2026
Same author

White matter resection and verbal memory deficits after temporal lobe epilepsy surgery.

Brain communications·2026
Same journal

Premature ventricular complexes.

Clinical medicine (London, England)·2026
Same journal

Heart failure with preserved ejection fraction (HFpEF): diagnosis and management for the general physician.

Clinical medicine (London, England)·2026
Same journal

Trends and Widening Inequities in Cardiovascular-Kidney-Metabolic Involvement in Cardiovascular Mortality: A National Spatiotemporal Analysis, 2014-2023.

Clinical medicine (London, England)·2026
Same journal

Educating current and future healthcare professionals on evidence-based sustainable medicine.

Clinical medicine (London, England)·2026
Same journal

UK Foundation Programme training needs a national minimum standard for advanced life support.

Clinical medicine (London, England)·2026
Same journal

Prognostic value of left atrial diameter in chronic kidney disease: The KNOW-CKD study.

Clinical medicine (London, England)·2026
See all related articles

Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Epilepsy often becomes refractory to antiepileptic drugs (AEDs) after initial treatment failures.
  • Refractory focal epilepsy significantly impacts quality of life and necessitates alternative treatment strategies.

Purpose of the Study:

  • To highlight the efficacy of neurosurgery in achieving long-term remission for refractory focal epilepsy.
  • To outline the comprehensive evaluation process for identifying surgical candidates.

Main Methods:

  • Standard evaluation includes clinical review, magnetic resonance imaging (MRI), scalp electroencephalography (EEG) with video, and neuropsychological/psychiatric assessments.
  • Advanced methods like functional imaging and intracranial EEG may be employed for complex cases.
  • Surgical interventions include anterior temporal lobe resection, lesionectomies, and neocortical resections.

Related Experiment Videos

Main Results:

  • Neurosurgery demonstrates a 60-70% chance of long-term remission in refractory focal epilepsy.
  • Standard and advanced evaluations aim to confirm a single epileptic focus and normal brain function elsewhere.
  • Palliative procedures like vagal nerve stimulation can reduce seizure frequency and severity.

Conclusions:

  • Patients with refractory focal epilepsy should be referred to specialized centers for neurosurgical evaluation.
  • A multidisciplinary approach ensures accurate diagnosis and optimal treatment selection for epilepsy management.