Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aerosolized surfactants.

Jan Mazela1, T Allen Merritt, Neil N Finer

  • 1Poznan University of Medical Sciences, Poland. janco@pol-med.com.pl

Current Opinion in Pediatrics
|May 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Less Invasive Surfactant Administration in Extreme Preterm Infants: A Systematic Review and Meta-Analysis.

Neonatology·2026
Same author

Clinical Burden and Healthcare Utilization Associated with Hospitalizations of RSV-Infected Polish Children During the 2022/23 Season.

Viruses·2026
Same author

Catch-Up Weight Gain and Gut Microbiota Development in Full-Term Small for Gestational Age Children During the First Year of Life-A Prospective Cohort Study.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Ultralow umbilical artery catheter placement: A large cohort analysis of safety in neonates.

The journal of vascular access·2026
Same author

The Umbilical Cord Clamp Method-Procedural Description and Safety Assessment of a Novel Method of Umbilical Catheter Fixation After Side Entry Insertion.

Life (Basel, Switzerland)·2025
Same author

Factors Influencing Unit-Level Differences in Prevalence of Prematurity-Associated Bronchopulmonary Dysplasia in a European Cohort: An Observational Study.

Chest·2025
Same journal

For health, for beauty, or both? navigating trends as adolescent clinicians.

Current opinion in pediatrics·2026
Same journal

Childhood sleep disorders: practical management for the pediatrician.

Current opinion in pediatrics·2026
Same journal

Advanced therapies in management of pediatric inflammatory bowel disease.

Current opinion in pediatrics·2026
Same journal

Artificial intelligence in pediatric endoscopy for hereditary polyposis syndromes: promises and challenges.

Current opinion in pediatrics·2026
Same journal

Hormonal acne therapies in pediatrics.

Current opinion in pediatrics·2026
Same journal

Clinical implementation of artificial intelligence in adolescent mental healthcare.

Current opinion in pediatrics·2026
See all related articles

Aerosolized surfactants offer a potential alternative to intubation for treating neonatal respiratory distress syndrome. Further research is needed to confirm the safety and efficacy of this novel delivery method.

Area of Science:

  • Neonatal Medicine
  • Pulmonology
  • Pharmacology

Background:

  • Current surfactant therapy for neonatal respiratory distress syndrome (NRDS) necessitates endotracheal intubation and positive pressure ventilation.
  • Direct instillation of surfactants can lead to adverse events such as desaturations, bradycardias, and reflux, potentially requiring reintubation.

Purpose of the Study:

  • To review existing data on aerosolized surfactants as a treatment for NRDS.
  • To explore alternative surfactant delivery methods in the context of increasing noninvasive ventilatory support.

Main Methods:

  • Review of animal models and four small clinical studies investigating aerosolized surfactants for NRDS.
  • Analysis of challenges including dose optimization, particle size, delivery systems, and formulation stability.

Related Experiment Videos

Main Results:

  • Aerosolized surfactant administration has shown promise in animal models of NRDS.
  • Preliminary clinical studies suggest potential, but effectiveness requires further investigation.
  • Key areas for future research include optimizing delivery parameters and surfactant formulation.

Conclusions:

  • Aerosolized surfactants may offer a less invasive alternative to endotracheal intubation for NRDS treatment.
  • Randomized controlled trials are essential to establish the safety and efficacy of aerosolized surfactant administration compared to traditional tracheal instillation.