Perioperative high-dose oxygen therapy in vascular surgery
Phillip J Puckridge1, Hafees A Saleem, Thodur M Vasudevan
1Department of Vascular Surgery, Waikato Hospital, Hamilton, New Zealand. phillip.puckridge@rgh.sa.gov.au
ANZ Journal of Surgery
|May 16, 2007
Summary
High-dose perioperative oxygen improved tissue oxygenation in vascular surgery patients postoperatively. This suggests potential benefits for reducing wound infections, though further research is needed.
Area of Science:
- Vascular Surgery
- Anesthesiology
- Wound Healing
Background:
- Infrainguinal bypass surgery patients exhibit low tissue oxygen and high infection rates.
- Surgical hypoxemia may impair the body's ability to fight bacterial infections.
- Investigating high-dose oxygen's impact on tissue oxygenation during surgery.
Purpose of the Study:
- To determine if high-dose perioperative oxygen increases tissue oxygenation in patients undergoing infrainguinal arterial surgery.
- To assess the effect of inspired oxygen concentration on transcutaneous partial pressure of oxygen (TcpO2).
Main Methods:
- Ten patients undergoing infrainguinal arterial surgery were studied.
- Transcutaneous partial pressure of oxygen (TcpO2) and arterial blood gases were measured.
- Inspired oxygen concentration (FiO2) was varied between 30% and 80% at different measurement points.
Main Results:
- No difference in intraoperative tissue oxygenation with clamps in place.
- Significantly higher postoperative tissue oxygenation observed with 80% FiO2 (P<0.05).
- Intraoperative increases in tissue carbon dioxide (P<0.01) and decreases in pH were noted.
Conclusions:
- High-dose oxygen increases tissue oxygen levels in vascular surgery patients when perfusion is not compromised.
- Intraoperative high-dose oxygen may help reduce surgical wound infections.
- Further research is necessary to confirm the benefits of high-dose oxygen in preventing wound infections.
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