Related Experiment Video
Updated: Jul 14, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
Published on: April 11, 2018
Does exercise during growth prevent fractures in later life?
1Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö University Hospital, Malmö, Sweden.
Regular weight-bearing exercise builds strong bones, potentially reducing fracture risk later in life. Long-term benefits may stem from retained bone structure and improved physical function, even after exercise cessation.
Area of Science:
- Exercise physiology
- Bone biology
- Gerontology
Background:
- Weight-bearing exercise during growth significantly enhances bone mass and structure.
- Long-term retention of exercise benefits is crucial for reducing age-related fragility fractures.
- Existing data suggest bone mineral density gains may diminish over time, but structural improvements might persist.
Purpose of the Study:
- To investigate the long-term impact of exercise on bone health and fracture risk.
- To explore whether exercise-induced skeletal and non-skeletal benefits persist after cessation of activity.
- To understand the potential for reduced fracture risk in former athletes.
Main Methods:
- Review of existing literature on exercise, bone health, and fracture risk.
- Analysis of studies examining long-term effects of exercise cessation.
- Consideration of retrospective observational and case-control studies on former athletes.
Main Results:
- Exercise during growth positively impacts bone mass and structure.
- Bone mineral density benefits may erode long-term, but structural adaptations might be retained.
- Former athletes may experience reduced fracture risk, possibly due to persistent skeletal and non-skeletal advantages.
Conclusions:
- A physically active lifestyle during growth is recommended for long-term fracture prevention.
- Retained bone structural properties and improved physical function may contribute to reduced fracture risk in later life.
- Further research is needed to establish causality and elucidate the mechanisms behind reduced fracture incidence in former athletes.
Related Concept Videos
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Growth of Cartilage and Bone Tissue
