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Sample Preparation for Analysis: Advanced Techniques

Sample Preparation for Analysis: Advanced Techniques

Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...

Sample Handling

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...

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Related Experiment Video

Updated: Apr 29, 2026

A Microfluidic Chip for ICPMS Sample Introduction

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Compound Hub: efficiency gains through innovative sample management processes.

Ulrich Schopfer¹, Marc R M Andreae, Matthieu Hueber

¹Novartis Institutes for BioMedical Research, Discovery Technologies, Basel, Switzerland. ulrich.schopfer@novartis.com

Combinatorial Chemistry & High Throughput Screening

|May 18, 2007

Summary

This summary is machine-generated.

The Compound Hub strategy streamlines compound sourcing for research by providing assay-ready samples. This innovation increases compound library capture by 75% and reduces errors through electronic tracking.

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Area of Science:

Drug Discovery and Development
Chemical Biology
Bioinformatics

Background:

Efficient sourcing of compounds from medicinal chemistry is a significant challenge in drug discovery.
Substantial investments are made to build and enhance compound libraries in both industry and academia.

Purpose of the Study:

To introduce the Compound Hub strategy for efficient compound sourcing and library expansion.
To improve accessibility of solubilized compounds for research laboratories.
To reduce errors and scientists' workload in sample preparation.

Main Methods:

Implementation of Central Compound Hubs in Basel and Cambridge.
Development of a web-based system for ordering compounds and assays.
Provision of assay-ready, solubilized compound samples to global research labs.
Electronic processing and tracking of compounds and assays.

Main Results:

Increased capture of medicinal chemistry compounds for the compound library by 75%.
Reduced error rates through electronic processing and tracking.
Scientists were relieved from time-intensive sample preparation tasks.
Provided assay-ready, solubilized samples to labs across the global research organization.

Conclusions:

The Compound Hub strategy effectively addresses challenges in compound sourcing.
This approach enhances compound library growth and research efficiency.
Electronic tracking and assay-ready samples improve data integrity and reduce workload.