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Updated: Jul 14, 2026
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Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates
Published on: May 29, 2018
Chimerism: a new look
Behrouz Nikbin1, Fatemeh Talebian, Mandana Mohyeddin
1Immunogenetic Research Center, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran. dnik@ams.ac.ir
Urology Journal
|May 22, 2007
Summary
Microchimerism involves foreign cells living within a host body, often seen after organ transplants. Ongoing research explores the long-term implications of these cells for host health and potential complications.
Area of Science:
- Cellular Biology
- Immunology
- Transplantation Science
Background:
- Microchimerism, the presence of foreign cells in a host, is gaining attention across various scientific fields.
- Research is investigating its potential roles in disease development and tissue repair.
- Understanding the mechanisms of microchimerism in the host body is a key focus.
Purpose of the Study:
- To review and synthesize current knowledge on microchimerism.
- To explore the phenomenon's implications in basic and medical sciences.
- To consolidate existing research on microchimerism.
Main Methods:
- Conducted a literature search on PubMed using terms related to chimerism.
- Reviewed all relevant papers published up to December 2005.
- Selected 61 papers for in-depth analysis.
Main Results:
- Microchimerism is defined as the presence, life, differentiation, and persistence of nonhost cells within a host.
- Commonly observed following organ transplantation, indicating recipient tolerance.
- Donor cell engraftment signifies successful transplantation and the establishment of a chimeric state.
Conclusions:
- The long-term fate and effects of microchimeric cells remain subjects of active investigation.
- Key questions include the duration of the chimeric state and potential for chronic complications.
- Researchers continue to explore the interactions between genetically distinct cell types within a single host.
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