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Updated: Jan 8, 2026

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Published on: October 17, 2025
Chronic myeloid leukaemia as a model of disease evolution in human cancer
1Department of Haematology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. j.melo@imperial.ac.uk
Abstract:
Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?
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