Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biosynthesis of Polysaccharides

Biosynthesis of Polysaccharides

Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...

Biosynthesis of Lipids

Biosynthesis of Lipids

Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discovery of Biased Dual-Agonists of Glucagon-Like Peptide 1 and Glucagon Receptors through Mutation of a Conserved Aspartate.

ACS medicinal chemistry letters·2026

Same author

Individual Differences in the "Cognitive-Adaptive Gap" Among Children with Autism Spectrum Disorder: A Latent Profile Analysis of the Moderating Role of Family Environment.

Journal of Intelligence·2026

Same author

Chloroplast sunscreening by protein condensates confers high-light tolerance.

Cell·2026

Same author

A high-throughput modular microfluidic platform for versatile functional assays at single-cell level.

Microsystems & nanoengineering·2026

Same author

Potentiation of a Porous Silicon Therapeutic Vaccine in Colorectal Cancer via Oxaliplatin-Mediated Regulation of Myeloid-Driven Immunosuppression.

Journal of functional biomaterials·2026

Same author

From KRAS<sup><i>G12D</i></sup> to Pan-KRAS Inhibitors─A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design.

Journal of medicinal chemistry·2026

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

The total synthesis of psymberin.

Xianhai Huang¹, Ning Shao, Anandan Palani

¹Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA. xianhai.huang@spcorp.com

Organic Letters

|May 26, 2007

Summary

The total synthesis of psymberin 1, a novel pederin family natural product, has been successfully achieved. This efficient synthesis utilized a key oxidative step to construct the complex tetrahydropyran core.

More Related Videos

13C6-Glucose Labeling Associated with LC-MS: Identification of Plant Primary Organs in Secondary Metabolite Synthesis

¹³C₆-Glucose Labeling Associated with LC-MS: Identification of Plant Primary Organs in Secondary Metabolite Synthesis

Published on: March 22, 2024

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Published on: July 17, 2020

Related Experiment Videos

Last Updated: Jul 14, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

13C6-Glucose Labeling Associated with LC-MS: Identification of Plant Primary Organs in Secondary Metabolite Synthesis

¹³C₆-Glucose Labeling Associated with LC-MS: Identification of Plant Primary Organs in Secondary Metabolite Synthesis

Published on: March 22, 2024

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Published on: July 17, 2020

Area of Science:

Natural product chemistry
Organic synthesis
Medicinal chemistry

Background:

The pederin family comprises potent biologically active natural products.
Psymberin 1 is a newly identified member of this family with potential pharmacological interest.
Total synthesis provides access to complex natural products for further study.

Purpose of the Study:

To achieve the first total synthesis of psymberin 1.
To develop an efficient and convergent synthetic route.
To establish a methodology for accessing pederin analogues.

Main Methods:

Convergent synthesis strategy.
Key step involving PhI(OAc)2 mediated oxidative entry to 2-(N-acylaminal)-substituted tetrahydropyrans.
Linear synthesis of 22 steps from known starting materials.

Main Results:

Successful completion of the total synthesis of psymberin 1.
Demonstration of an efficient and convergent synthetic approach.
Validation of the novel oxidative key step for tetrahydropyran construction.

Conclusions:

The total synthesis of psymberin 1 is now feasible.
The developed synthetic route is efficient and convergent.
This work provides a platform for the synthesis of related pederin natural products.