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Clinical contrast sensitivity testing in patients with infantile nystagmus syndrome compared with age-matched
Richard W Hertle1, Matthew Reese
1Division of Ophthalmology, Children's Hospital of Pittsburgh, Pennsylvania 15213, USA. Richard.Hertle@chp.edu
Purpose:
To compare contrast sensitivity using a commercially available technique between patients with infantile nystagmus syndrome (INS) and controls.
Design:
Prospective, comparative case series.
Methods:
The functional acuity contrast test (FACT) was used binocularly in patients with INS and aged-matched controls with best acuity under normal lighting using a progression of high-quality sine wave grating size changes with increasing spatial frequencies.
Results:
Nine INS patients aged 5 to 11 years and 25 controls were tested. The INS patients' best binocular acuity ranged from 20/125 to 20/30, and that of the controls was 20/25 or better. When compared with age-matched controls, INS patients displayed deficiencies in contrast sensitivity syndrome using the FACT test.
Conclusions:
The FACT or a similar testing system may have potential as a commercially available outcome measure in clinical trials in patients with INS.
