[Autoregulation of cerebral blood flow in condition of experimental hepatic encephalopathy]

The linear interrelation between Systemic Arterial Blood Pressure and local Cerebral Blood Flow has been shown in experiments on rats with induced experimental hepatic encephalopathy. This is evidence of complete malfunctioning of the mechanism of Cerebral Blood Flow Autoregulation. Quantitative comparison of local Cerebral Blood Flow intensity in control and experimental (Hepatic Encephalopathy) animals has shown significant increase of the basic level of cerebral blood flow in rats with induced Hepatic Encephalopathy (p<0,05). On the basis of own and literature data the chain of developments in experimental hepatic encephalopathy was drawn: excess of Nitric Oxide because of hepatic failure can cause the cerebral vasodilatation with inadequate increase of cerebral blood flow intensity, resulting in malfunction of the cerebral blood flow autoregulation, increase of Blood Brain Barrier permeability, and penetration of toxic substances in nervous tissue. As a result of these--cognitive deficiency is developed (at the best) and hepatic coma (at the worst).