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Updated: Jul 14, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
Published on: November 4, 2022
In vivo pharmacokinetic and metabolism studies of ginsenoside Rd
Liu Yang1, Yuanhui Deng, Shunjun Xu
1Second Affiliated Hospital, Guangzhou University of TCM, Guangzhou 510120, PR China. yangliume@yahoo.com
Abstract:
A high-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry (LC-ESI-MS(n)) method has been developed to determine ginsenoside Rd in human plasma and to identify its metabolites in rat urine. The plasma and urine samples were pretreated by solid phase extraction (SPE) prior to analyses. In this work, gentiopicroside was used as the internal standard. The lower limit of quantification (LLOQ) for Rd in human plasma was 3 ng/ml. The average half-life time in plasma was detected as 19.29 h, when 10 mg of ginsenoside Rd was administrated intravenously to the volunteers. Seven metabolites including three oxygenated, two combined and two hydrolyzed components were identified in rat urine samples by using LC-MS and MS-MS, when ginsenoside Rd administered either orally or intravenously.
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