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Related Experiment Video

Updated: Jul 14, 2026

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

Published on: January 2, 2017

Antiphospholipid antibody effects on monocytes.

Alisa S Wolberg¹

¹Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7525, USA. alisa_wolberg@med.unc.edu

Current Rheumatology Reports

|May 29, 2007

Summary

Autoantibodies in antiphospholipid syndrome increase thrombosis risk. Targeting monocyte activation offers a novel, safer therapeutic approach than current antithrombotics.

Area of Science:

Immunology
Hematology
Pathobiology

Background:

Antiphospholipid syndrome (APS) is linked to increased thrombosis risk, driven by autoantibodies.
The precise mechanisms of autoantibody-induced thrombosis in APS remain unclear.
Monocyte dysregulation is implicated as a key pathobiologic mechanism in APS.

Purpose of the Study:

To investigate the role of autoantibodies in monocyte activation and procoagulant activity in APS.
To explore novel therapeutic strategies targeting monocyte pathways for APS treatment.

Main Methods:

Review of recent studies on monocyte activation in APS.
Analysis of extracellular and intracellular interactions in monocyte function.

Main Results:

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Last Updated: Jul 14, 2026

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Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

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Published on: October 17, 2017

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Autoantibody-mediated dysregulation of monocytes is a significant factor in APS pathogenesis.
Monocyte activation and expression of procoagulant activity are critical in disease progression.

Conclusions:

Targeting monocyte activation presents a promising, potentially safer therapeutic avenue for APS.
Novel agents focused on monocyte pathways may offer an alternative to existing antithrombotic treatments.