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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

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Related Experiment Video

Updated: Jul 14, 2026

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
08:25

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

Pneumococcal hemolytic uremic syndrome.

A Gite1, S Bhide

  • 1Department of Pediatrics, Darent Valley Hospital, Dartford, UK. DA2 8DA

Indian Pediatrics
|May 31, 2007
PubMed
Summary

Streptococcus pneumoniae can cause Hemolytic Uremic Syndrome (HUS) in children. This case shows a 20-month-old girl with HUS who improved with hemodialysis treatment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Nephrology

Background:

  • Hemolytic Uremic Syndrome (HUS) is a serious condition often associated with E. coli infections.
  • Streptococcus pneumoniae is a common pathogen, but its role in HUS is less frequently reported.

Observation:

  • A 20-month-old female presented with symptoms suggestive of HUS.
  • The patient had a confirmed Streptococcus pneumoniae infection.

Findings:

  • The clinical presentation was consistent with HUS.
  • The child demonstrated a positive response to hemodialysis.
  • Resolution of HUS symptoms was observed following treatment.

Implications:

  • This case highlights Streptococcus pneumoniae as a potential causative agent of HUS in pediatric patients.

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Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
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Last Updated: Jul 14, 2026

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  • Early recognition and supportive care, including hemodialysis, are crucial for managing HUS.
  • Further research may elucidate the mechanisms by which S. pneumoniae induces HUS.