Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucociliary function following sinus mucosal regeneration.

M S Benninger1, J L Schmidt, J D Crissman

  • 1Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202-2689.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adjustable collimation for dark-field proton radiography contrast enhancement.

The Review of scientific instruments·2026
Same author

Design and commissioning of the PRIOR-II "proton microscope for FAIR".

The Review of scientific instruments·2024
Same author

Large-grain scintillator screens for proton radiography.

The Review of scientific instruments·2024
Same author

Robust unfolding of MeV x-ray spectra from filter stack spectrometer data.

The Review of scientific instruments·2024
Same author

Measurement of anisotropic mechanical properties in porcine brain white matter ex vivo using magnetic resonance elastography.

Journal of the mechanical behavior of biomedical materials·2017
Same author

Magnetic resonance elastography of slow and fast shear waves illuminates differences in shear and tensile moduli in anisotropic tissue.

Journal of biomechanics·2016
Same journal

Otovent Versus Valsalva: Physiological Insights for Diagnostic and Therapeutic Autoinflation in Eustachian Tube Dysfunction.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

CSNK1A1 Mediates Inner Ear Inflammation and Endolymphatic Hydrops in a Lipopolysaccharide-Induced Mouse Model.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Medial Flap Versus Coblation-Assisted Turbinoplasty For Turbinates Hypertrophy: A Prospective Randomized Controlled Trial.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Gender-Affirming Care in Otolaryngology: A State of the Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Caffeine Consumption and Rhinologic Symptom Severity.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Ethical Considerations in Using the Pernkopf Atlas in Otolaryngology Education Ethics in Practice: Point-Counterpoint.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
See all related articles

Surgical removal of rabbit maxillary sinus mucosa showed partial ciliary regeneration but significant fibrosis and inflammation. Regenerated cilia often displayed abnormalities, impacting overall sinus mucosal healing.

Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Histopathology

Background:

  • Surgical interventions for sinus diseases often involve mucosa removal.
  • Understanding the regenerative capacity and functional recovery of sinus mucosa is crucial for patient outcomes.
  • Limited data exists on the detailed characteristics of regenerated sinus mucosa post-surgery.

Purpose of the Study:

  • To investigate the regeneration of maxillary sinus mucosa after surgical removal in rabbits.
  • To assess the motility and ultrastructure of regenerated cilia.
  • To characterize the histopathological changes in the operated sinus mucosa.

Main Methods:

  • Unilateral maxillary sinus mucosa removal in 15 rabbits, with contralateral sinuses as controls.
  • Specimen collection after 10 weeks for microscopic examination.

Related Experiment Videos

  • Utilized light microscopy, dark-field microscopy, and electron microscopy.

    • Main Results:

    • Ciliary regeneration observed in 8/15 operated sinuses via light microscopy.
    • Motile cilia identified in 6/8 regenerated sinuses using dark-field microscopy.
    • Histopathology revealed fibrosis, reduced glands, and inflammation; electron microscopy showed abnormal cilia structure and reduced density.

    Conclusions:

    • Maxillary sinus mucosa exhibits partial regenerative capacity after surgical removal.
    • Regenerated cilia may have impaired motility and ultrastructural abnormalities.
    • Significant histopathological changes like fibrosis and inflammation accompany regeneration, suggesting incomplete functional recovery.