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Updated: Jul 14, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

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Published on: March 14, 2017

[Management of hemochromatosis linked to HFE gene]

Pierre Brissot1, Frédéric De Bels

  • 1Service des maladies du foie, Inserm U-522 et IFR140, CHU Pontchaillou, Rennes. pierre.brissot@univ-rennes1.fr

Presse Medicale (Paris, France : 1983)
|June 8, 2007
PubMed

Phenotypic expression of the homozygous C282Y/C282Y mutation of the HFE gene has been classified in five stages, and appropriate management recommended for each stage. Phlebotomy is indicated for stages>or=2, that is, with elevated transferrin saturation and serum ferritin levels >300 microg/L in men and >200 microg/L in women. Maximal volume per phlebotomy is 7 mL/kg and should not exceed 550 mL. The main goal of this iron-depletion therapy is to reach and maintain serum ferritin levels

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