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Updated: Jul 14, 2026
11:55
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Wernicke's encephalopathy after allogeneic stem cell transplantation.
Giuseppe Messina1, Eugenia Quartarone, Giuseppe Console
1Centro Trapianti Midollo Osseo "A. Neri", Azienda Ospedaliera "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy. gspmessina@virgilio.it
Tumori
|June 15, 2007
Summary
Wernicke
Area of Science:
- Neuroscience
- Internal Medicine
Background:
- Wernicke's encephalopathy is an acute neuropsychiatric condition linked to thiamine deficiency, often seen in chronic alcohol abuse.
- Allogeneic stem cell transplantation (ASCT) is a complex procedure with potential nutritional challenges.
Observation:
- Two patients developed acute Wernicke's encephalopathy following ASCT.
- The condition was associated with the use of commercial total parenteral nutrition (TPN).
Findings:
- Magnetic resonance imaging (MRI) enabled early diagnosis of Wernicke's encephalopathy.
- Prompt thiamine treatment led to rapid clinical and radiological improvement.
Implications:
- Prolonged use of commercial TPN requires thiamine supplementation.
- Intramuscular multivitamins are recommended for TPN patients to prevent thiamine deficiency.
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