Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Threshold Dose--Response Model--RIP: 1911 to 2006.

Edward J Calabrese1

  • 1Environmental Health Sciences, University of Massachusetts, North Pleassant St Amherst MA 01003, USA. edwardc@schoolph.umass.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The crucible of resilience: hormesis as the unifying principle of evolution, genetics, and epigenetics.

Archives of toxicology·2026
Same author

Hormesis in biomedical and toxicological models: A generalizable phenomenon induced by per- and polyfluoroalkyl agents.

Chemico-biological interactions·2026
Same author

Canine environmental health: An EPA blind spot? Canine physiology, environmental exposure, and the regulatory gap in U.S. policy.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Hormetic effects of per- and polyfluoroalkyl substances on ecologically relevant animal models: Generality, quantitative features, and risk assessment implications.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

How the US NAS BEAR I Genetics Panel scientific misconduct could have been avoided, but was not.

Journal of occupational and environmental hygiene·2026
Same author

BEAR I Genetics Panel: An unexpected and troubling historical twist: The untold story of Hermann Muller's significant scientific confusion.

Journal of occupational and environmental hygiene·2026
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

The Threshold Dose-Response Model, a long-standing concept in toxicology, is being symbolically retired. New evidence shows its inadequacy in predicting low-dose effects, necessitating a re-evaluation of toxicological models.

Area of Science:

  • Toxicology
  • Biomedical Sciences
  • Risk Assessment

Background:

  • The Threshold Dose-Response Model has been a cornerstone in toxicology and biomedical sciences for decades.
  • It posits a safe exposure level below which no adverse effects occur.
  • This model has guided regulatory decisions and scientific research.

Observation:

  • Recent scientific evidence challenges the predictive power of the Threshold Dose-Response Model, particularly at low exposure levels.
  • The model's limitations in accurately forecasting low-dose effects have become increasingly apparent.
  • This has led to a critical re-examination of its fundamental assumptions.

Findings:

  • The Threshold Dose-Response Model demonstrates significant shortcomings in predicting responses to low doses of substances.

Related Experiment Videos

  • Its utility for assessing risks associated with minimal exposures is questionable.
  • The model's historical dominance is being questioned due to emerging data.

    • Implications:

    • A paradigm shift in toxicological modeling may be necessary to better understand and predict low-dose effects.
    • Rethinking established risk assessment frameworks is crucial for public health and environmental safety.
    • Future research should focus on developing and validating alternative models that accurately capture low-dose phenomena.