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Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors

Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors

Published on: September 24, 2014

Tumorigenesis in the brain: location, location, location.

Richard J Gilbertson¹, David H Gutmann

¹Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. Richard.Gilberston@stjude.org

Cancer Research

|June 19, 2007

Summary

Brain tumors originate from cancer stem cells. Tumors appearing similar but from different brain areas are molecularly distinct, arising from unique progenitor cells.

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Area of Science:

Neuro-oncology
Stem cell biology
Cancer genetics

Background:

Emerging evidence suggests brain tumors originate from cancer stem cells.
Cancer stem cells possess stem cell or neuroglial progenitor cell properties.

Purpose of the Study:

To investigate the origin and molecular distinctness of brain tumors.
To explore the role of progenitor cells and tumor microenvironment in central nervous system tumor evolution.

Main Methods:

Analysis of histological and molecular data from brain tumors.
Comparison of tumors from different brain regions.

Main Results:

Histologically similar tumors from different brain regions exhibit molecular differences.
These differences are attributed to distinct, site-restricted progenitor cell populations.

Conclusions:

Brain tumors arise from specific progenitor cells, not a single cell type.
Tumor origin, microenvironment, and genetic alterations interact to drive central nervous system tumor development.