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Childhood Atopic Dermatitis Impact Scale: reliability, discriminative and concurrent validity, and responsiveness
Sarah L Chamlin1, Jin-Shei Lai, David Cella
1Division of Pediatric Dermatology, Children's Memorial Hospital, Chicago, IL 60614, and Center on Outcomes Research and Education, Evanston Northwestern Healthcare and Northwestern Feinberg School of Medicine, USA. schamlin@childrensmemorial.org
The Childhood Atopic Dermatitis Impact Scale (CADIS) reliably measures quality of life in children with atopic dermatitis. This validated scale accurately reflects disease severity and treatment improvements.
Area of Science:
- Pediatric Dermatology
- Quality of Life Assessment
- Atopic Dermatitis Research
Background:
- Atopic dermatitis significantly impacts children's quality of life.
- Validated tools are essential for assessing quality of life in pediatric dermatology.
- The Childhood Atopic Dermatitis Impact Scale (CADIS) is a novel quality-of-life measure.
Purpose of the Study:
- To evaluate the test-retest reliability of the CADIS.
- To assess the discriminative and concurrent validity of the CADIS.
- To determine the responsiveness of the CADIS to changes in atopic dermatitis severity.
Main Methods:
- Prospective, longitudinal study conducted in pediatric dermatology practices.
- 301 parents of children under 6 with atopic dermatitis participated.
- CADIS, sociodemographic data, and clinical questions administered at baseline and 4-week follow-up; test-retest reliability assessed at 48 hours. Disease severity measured by SCORAD index.
Main Results:
- High test-retest reliability for CADIS scores (Intraclass correlation coefficients 0.89–0.95).
- Significant correlations between CADIS and SCORAD scores (0.42–0.72), indicating worse quality of life with increased severity.
- CADIS domains significantly differentiated severity levels (P<.001) and detected improvements at 4 weeks (P<.05).
Conclusions:
- The Childhood Atopic Dermatitis Impact Scale (CADIS) demonstrates strong test-retest reliability and validity.
- The CADIS is a responsive measure, accurately reflecting changes in quality of life.
- CADIS is a valuable tool for assessing quality of life in pediatric atopic dermatitis.
