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Updated: Jul 14, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
[Physiological blocking of the mechanisms of the cold death]
Abstract:
Physiological mechanisms of the cold paralyses of the main, most important functions during deep hypothermia of a homeothermic organism were studied. The reasons for the organism death upon deep cooling were revealed. The cold paralyses and the following organism death were shown to be accounted for to a great extent by the specific impairments in the ion exchange between the nervous cells of vegetative brain centers and the intercellular medium and the blood. Removing these impairments with the help of the methods developed in the authors laboratory allows the lost physiological functions of an organism to be restored for a time without rewarming the body.
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