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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Maintenance of the Cardiovascular Function in a Deeply Cooled Homeothermic Organism by Physiological Methods without
1I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. kpivanov@nc2490.spb.edu.
Abstract:
Gradual cooling of homeothermic organisms is followed by slowing and arrest of breathing and heart contractions. During deep cooling, even relatively slight artificial ventilation decreases the lower temperature limit of life (by 4.5-5°C) and provides minimum oxygen supply to the heart and whole body. This allows us to restore cardiovascular function and prevent animal death after lethal cooling without eternal warming.
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