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Updated: Jul 14, 2026
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Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
Endometrioid adenocarcinoma with a functioning stroma
Tadashi Hayasaka1, Kenji Nakahara, Takanobu Kojimahara
1Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata, Japan.
The Journal of Obstetrics and Gynaecology Research
|June 21, 2007
Summary
This rare case highlights endometrioid adenocarcinoma of the ovary with functioning stroma, presenting as postmenopausal bleeding due to high estradiol levels. Surgical removal normalized hormone levels, confirming the tumor
Area of Science:
- Gynecologic Oncology
- Reproductive Endocrinology
Background:
- Ovarian tumors frequently exhibit endocrine abnormalities.
- Endometrioid adenocarcinoma with functioning stroma is a rare subtype.
- Functioning ovarian stroma can lead to hormonal imbalances.
Observation:
- A 70-year-old woman presented with postmenopausal bleeding.
- Preoperative findings included elevated serum estradiol and suppressed gonadotropins.
- Imaging revealed a large ovarian tumor and an enlarged uterus.
Findings:
- Histopathology confirmed endometrioid adenocarcinoma of the ovary with functioning stroma.
- Tumor cells resembled early secretory endometrial cells.
- Stromal cells showed features similar to theca lutein cells.
Implications:
- Surgical resection led to decreased estradiol and increased follicle-stimulating hormone levels.
- This case underscores the importance of considering rare ovarian tumors in endocrine disturbances.
- Understanding functioning ovarian stroma is crucial for diagnosing and managing such conditions.
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