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Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jul 14, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

[Anaphylaxis after carrying out prick tests].

S Vázquez-Cortés¹, T Robledo Echarren, B Bartolomé

¹Servicio de Alegia, Hospital Clínico Universitario San Carlos, Madrid. cmcocera@meditex.es

Anales De Medicina Interna (Madrid, Spain : 1984)

|June 26, 2007

Summary

Skin prick testing (SPT) can rarely cause severe allergic reactions like anaphylaxis. This case highlights the risk of anaphylaxis after SPT with cat dander extract, emphasizing the need for preparedness.

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Last Updated: Jul 14, 2026

Measuring Local Anaphylaxis in Mice

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Published on: October 14, 2014

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Published on: May 31, 2021

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

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Published on: September 14, 2018

Area of Science:

Allergology
Immunology
Dermatology

Background:

Skin prick testing (SPT) is a standard diagnostic tool in allergology.
While generally safe, rare systemic reactions, including anaphylaxis, have been reported.
Cat dander allergy is common, often presenting with respiratory and ocular symptoms.

Observation:

A 23-year-old female with a history of asthma and rhinoconjunctivitis experienced anaphylaxis post-SPT.
The reaction occurred 20 minutes after SPT using a cat dander extract.
Symptoms included severe ocular irritation, dysphonia, and a sensation of pharyngeal occupation.

Findings:

The patient developed anaphylaxis with hemodynamic compromise following SPT.
Cat dander extract was identified as the trigger for the severe systemic reaction.
This case underscores the potential for serious adverse events during SPT.

Implications:

SPT should be conducted by trained specialists in facilities equipped to manage anaphylaxis.
Awareness of potential systemic reactions is crucial for patient safety during allergy testing.
Prompt recognition and management are vital for patients experiencing anaphylaxis after SPT.