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[Mantle cell lymphoma].

P Khosravi Shahi1, A Del Castillo Rueda, G Pérez Manga

  • 1Servicio de Oncología Medica, Servicio de Medicina Interna II, Hospital General Universitario Gregorio Marañon, Madrid. drkhosravi@hotmail.com

Anales De Medicina Interna (Madrid, Spain : 1984)
|June 26, 2007
PubMed
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Mantle cell lymphoma is a B-cell neoplasm comprising 7% of adult Non-Hodgkin Lymphomas. Diagnosis relies on nuclear cyclin D1 protein, and while incurable, treatments include chemotherapy and stem cell transplantation.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Context:

  • Mantle cell lymphoma (MCL) represents approximately 7% of adult Non-Hodgkin Lymphomas.
  • It is characterized by monomorphic small to medium-sized B cells with irregular nuclei.
  • Tumor cells typically express strong IgM, IgD, and B-cell-associated antigens.

Purpose:

  • To outline the diagnostic criteria and genetic underpinnings of Mantle Cell Lymphoma.
  • To describe the clinical presentation and current treatment strategies for MCL.
  • To highlight the prognostic factors and therapeutic approaches for this B-cell neoplasm.

Summary:

  • Mantle cell lymphoma is diagnosed by the presence of nuclear cyclin D1 protein, a gold standard.
  • The genetic hallmark is the t(11;14) translocation, leading to BCL-1 locus rearrangement and cyclin D1 gene overexpression.

Related Experiment Videos

  • Most patients present with disseminated disease, and MCL is considered an incurable but treatable neoplasm.

    • Impact:

    • Advances in understanding MCL pathogenesis and diagnosis.
    • Identification of key biomarkers for accurate diagnosis and targeted therapy.
    • Improved therapeutic strategies including chemotherapy regimens and stem cell transplantation offer management options for patients.