Quantification of burst suppression and bispectral index with 2 different bolus doses of thiopentone sodium

Metabolic suppression caused by barbiturates is a major mechanism responsible for their cerebral protective potential. Maximal cerebral metabolic suppression is believed to coincide with electroencephalographic burst suppression. However, many neurosurgical procedures associated with cerebral ischemic threat are still performed in the absence of electroencephalogram monitoring, especially in developing nations. The present study was designed to assess the degree of burst suppression with 2 different doses of thiopentone sodium administered on the background of isoflurane anesthesia intraoperatively. Forty-one patients without any intracranial pathology undergoing elective spinal surgery under a general anesthetic consisting of N2O (60%) in O2 (40%) and isoflurane to maintain a bispectral index (BIS) value of 45 were randomized to receive a thiopentone bolus of either 3 or 5 mg/kg. BIS, burst suppression ratio (BSR), systolic blood pressure, and heart rate were recorded before the bolus and every 15 seconds for first 2 minutes and every 30 seconds for another 8 minutes. During the 10-minute study period after the administration of thiopentone bolus, BIS values were significantly lower in the group that received thiopentone 5 mg/kg compared with the group that received thiopentone 3 mg/kg (P<0.02). BSR>25% was seen in 7 out of 21 patients in the 3 mg/kg group and 10 out of 20 patients in the 5 mg/kg group. There was a statistically insignificant prolongation of the duration of burst suppression with thiopentone 5 mg/kg [243 s (range 75 to 435 s)] compared with thiopentone 3 mg/kg [171 s (30 to 465 s)]. The number of patients who had a BSR >50% was higher among patients who received thiopentone 5 mg/kg as compared with those who received a dose of 3 mg/kg [9/20 vs. 3/21(P<0.02)]. We conclude that thiopentone in a bolus dose of 3 to 5 mg/kg produces only a short duration of incomplete burst suppression. Also, in this dose range, burst suppression does not occur consistently in all patients. The present data suggest that bolus doses of thiopentone in the range of 3 to 5 mg/kg may have very limited value in providing significant metabolic suppression required for intraoperative cerebral protection during temporary ischemic episodes.