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Factors that correlate with sleep oxygenation in children with cystic fibrosis

Z S Uyan1, N Ozdemir, R Ersu

  • 1Division of Pediatric Pulmonology, Marmara University, Istanbul, Turkey. zeynepsedau@yahoo.com

Pediatric Pulmonology
|June 28, 2007
PubMed

Insights

Cystic fibrosis (CF) patients with normal or mild lung disease experience nocturnal oxygen desaturation. Lower nocturnal oxygen saturation in these children correlates with lung disease severity scores and blood gas levels.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Cystic Fibrosis Research

Background:

  • Cystic fibrosis (CF) can lead to nocturnal hypoxemia, particularly in children.
  • Limited data exists on nocturnal oxygen saturation in pediatric CF patients with less severe lung disease.

Purpose of the Study:

  • To assess nocturnal oxygen desaturation in CF children with normal or mild-to-moderate lung disease.
  • To identify factors correlating with nocturnal oxygenation in this pediatric CF population.

Main Methods:

  • Overnight pulse oximetry was used to monitor SpO2 in 24 CF children.
  • Evaluated parameters included pulmonary function tests (PFTs), Six Minutes Walk Test (6MWT), Shwachman-Kulczycki (S-K), Brasfield, and CT scores, blood gas analysis, and nutritional status.

Main Results:

  • Nocturnal mean SpO2 did not vary by PFT-defined lung disease severity.
  • Lowest SpO2 was significantly lower in children with mild/moderate disease (87.4%) versus normal (91.7%).
  • 95.8% of participants experienced desaturation events; nocturnal SpO2 correlated with S-K, Brasfield, CT scores, PaO2, and SaO2.

Conclusions:

  • Nocturnal oxygenation in pediatric CF patients with normal or mild-to-moderate lung disease is frequently impaired.
  • Nocturnal oxygen saturation correlates with clinical and imaging markers of lung disease severity and blood gas levels.
Abstract

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