Related Experiment Video
Updated: Jul 14, 2026
08:35
Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
Published on: June 24, 2021
AVATAR: a database for genome-wide alternative splicing event detection using large scale ESTs and mRNAs
Fang Rong Hsu1, Hwan-You Chang, Yaw-Lin Lin
1Bioinformatics Research Center, Department of Information Engineering and Computer Science, Feng Chia University, Taiwan. frhsu@fcu.edu.tw
Bioinformation
|June 29, 2007
Summary
AVATAR is a new database documenting alternative splicing (AS) variants using millions of human sequences. It identifies thousands of AS sites and provides visualized data for queried genes.
Area of Science:
- Bioinformatics
- Genomics
- Molecular Biology
Background:
- Alternative splicing (AS) variant identification is increasingly important.
- Databases are crucial for organizing and accessing complex biological data.
Purpose of the Study:
- To develop AVATAR, a comprehensive database for documenting alternative splicing variants.
- To provide a user-friendly platform for querying and visualizing AS information.
Main Methods:
- Utilized 5,469,433 human EST sequences and 26,159 human mRNA sequences.
- Mapped EST and mRNA sequences to the human genome to identify AS sites.
- Developed a graph model representing exons and introns for AS data analysis.
- Included AS information for 6 eukaryotic species.
Main Results:
- Identified 12,000 alternative splicing sites.
- AVATAR database integrates extensive human AS data.
- The system supports querying by gene names, number of AS events, and supporting ESTs.
- Visualized AS information is provided for queried genes.
Conclusions:
- AVATAR offers a valuable resource for researchers studying alternative splicing.
- The database facilitates the exploration and understanding of AS diversity across species.
- The visualized output aids in the interpretation of complex AS patterns.
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There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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