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Updated: Jul 14, 2026

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
08:43

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

Published on: November 30, 2012

Targeted therapy and blood-brain barrier

Agnieszka Korfel1, Eckhard Thiel

  • 1Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charité Universitätsmedizin Berlin, Germany.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|July 5, 2007
PubMed

Insights

Targeted therapy shows promise for brain tumors due to molecular targets. However, the blood-brain barrier poses challenges for effective treatment delivery and clinical outcomes.

Area of Science:

  • Neuro-oncology
  • Molecular neuroscience
  • Cancer therapy

Background:

  • Brain tumors exhibit specific molecular lesions and signaling pathway disruptions.
  • These characteristics make them suitable candidates for targeted therapy.
  • The blood-brain barrier (BBB) impedes drug delivery, limiting therapeutic efficacy.

Purpose of the Study:

  • To review advanced targeted therapy strategies for brain tumors.
  • To present current clinical results of these targeted treatments.
  • To discuss the impact of the blood-brain barrier on targeted therapy.

Main Methods:

  • Literature review of advanced targeted therapy modalities.
  • Analysis of clinical trial data for targeted brain tumor treatments.
  • Discussion of molecular targets and signaling pathways in brain tumors.

Main Results:

  • Several advanced targeted therapies are under investigation for brain tumors.
  • Clinical outcomes vary depending on the specific therapy and tumor type.
  • The blood-brain barrier remains a significant obstacle in delivering targeted agents.

Conclusions:

  • Targeted therapy holds potential for brain tumor treatment.
  • Overcoming the blood-brain barrier is crucial for therapeutic success.
  • Further research is needed to optimize targeted drug delivery and efficacy.

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