Related Experiment Video
Updated: Jul 13, 2026

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum
Published on: January 26, 2024
[The relation of peroxisome proliferator activated receptorbeta and Epithelial Ovarian Carcinoma]
Ying Yang1, Jian-qing Hou, Hong-Wei Ju
1Department of Anatomy, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Aim:
To explore the possible relationship between expression of PPAR(pevoxisome prodiferator adivated receptor) beta and clinical pathological features of epithelial ovarian carcinoma (EOC).
Methods:
PPARbeta expressions in normal ovaries (n=10), ovarian bordline tumors (n=10), and ovarian serous cystadenocarcinomas (n=46) were investigated by immunohistochemistry and RT-PCR.
Results:
PPARbeta protein was expressed in normal ovaries and ovarian cancer. PPARbeta protein was found in cytoplasm of tumor cell. PPARbeta expression was 20% revealed in normal ovaries, 50% in bordline tumors 89.1% in serous cystadenocarcinomas(P<0.05), significantly higher than that in bordline tumors (P<0.05). PPARbeta expression was positively correlated with tumor stage, histological grade and lymphonode metastasis (P<0.05).
Conclusion:
High expression of PPARbeta may be related with the differentiation and metastasis of epithelial ovarian carcinoma.
Related Concept Videos
Peroxisomes
Peroxisomes
Peroxisomes
Oogenesis
Mitogens and the Cell Cycle
Protein Import into the Peroxisomes
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...

