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Developments in ion chromatography using monolithic columns.

Stuart D Chambers1, Karen M Glenn, Charles A Lucy

  • 1Department of Chemistry, University of Alberta, Gunning/Lemieux Chemistry Centre, Edmonton, Alberta, Canada.

Journal of Separation Science
|July 12, 2007
PubMed
Summary
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Monolithic phases in ion chromatography (IC) offer high efficiency for separating inorganic ions. Developments focus on improving ion exchange capacity and exploring applications beyond columns.

Area of Science:

  • Analytical Chemistry
  • Chromatography

Background:

  • Ion chromatography (IC) is a key analytical technique.
  • Monolithic stationary phases are emerging as advanced materials in chromatography.

Purpose of the Study:

  • To review the current status and ongoing developments of monolithic phases in ion chromatography.
  • To discuss the potential and applications of silica and polymeric monoliths in IC.

Main Methods:

  • Review of existing literature on monolithic phases for IC.
  • Discussion of methods for introducing ion exchange capacity onto monoliths (reagents, coatings, covalent bonding).
  • Tabulation of applications for inorganic anion and cation separations.

Main Results:

  • Silica monoliths achieve high efficiencies (>10^5 plates/m) for inorganic ion separation in minutes.

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  • Various methods exist to impart ion exchange capacity, with surfactant coatings being common but limited by stability.
  • Monolithic columns show promise for IC peripherals like preconcentrators and suppressors.

    • Conclusions:

    • Monolithic phases represent a significant advancement in ion chromatography, offering high performance and versatility.
    • Commercialization of monolithic IC columns is underway, expanding their practical use.
    • Further research into stable monolithic materials and applications is warranted.