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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Published on: April 23, 2019

[Hyponatremia due to tramadol].

J-P Le Berre1, J Desramé, S Lecoules

  • 1Service de médecine interne, hôpital d'instruction des armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75230 Paris cedex 05, France. mjpleberre@cfibre.fr

La Revue De Medecine Interne
|July 13, 2007
PubMed
Summary

Tramadol can cause hyponatremia, a dangerous drop in sodium levels, especially in elderly patients. Monitoring sodium levels is crucial if neurological symptoms arise during tramadol treatment.

Related Experiment Videos

Last Updated: Jul 13, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Area of Science:

  • Geriatric Medicine
  • Clinical Pharmacology
  • Endocrinology

Background:

  • Hyponatremia is a common electrolyte imbalance, particularly in the elderly.
  • Tramadol is an opioid analgesic frequently prescribed for pain management.
  • Antidiuretic hormone (ADH) plays a critical role in regulating water balance.

Observation:

  • A 92-year-old woman developed severe hyponatremia (117 mmol/l) three days after starting tramadol.
  • Neurological abnormalities were present in the patient.
  • Blood and urine analyses confirmed the diagnosis of inappropriate antidiuretic hormone secretion (SIADH).

Findings:

  • Tramadol initiation was temporally associated with the onset of hyponatremia.
  • Cessation of tramadol and fluid restriction led to normalization of serum sodium levels.
  • The patient's condition improved significantly after discontinuing the medication.

Implications:

  • Tramadol should be used cautiously in elderly patients due to the risk of hyponatremia.
  • Physicians should consider measuring serum electrolytes in patients experiencing neurological changes while on tramadol.
  • Early recognition and management of drug-induced hyponatremia are essential for patient safety.