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Updated: Jul 13, 2026
12:18
Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Solid-supported monolayers and bilayers of amphiphilic beta-cyclodextrins.
Antonella Cristiano1, Choon Woo Lim, Dorota I Rozkiewicz
1Laboratory of Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, Netherlands.
Langmuir : the ACS Journal of Surfaces and Colloids
|July 13, 2007
Summary
Beta-cyclodextrin (CD) vesicles form supported monolayers or bilayers on patterned surfaces. These supramolecular platforms selectively bind guest molecules, enabling patterned host-guest interactions.
Area of Science:
- Supramolecular Chemistry
- Surface Science
- Materials Science
Background:
- Beta-cyclodextrin (CD) vesicles undergo structural transitions upon adsorption to surfaces.
- Understanding these transitions is crucial for developing novel functional materials.
Purpose of the Study:
- To investigate the adsorption and spreading behavior of beta-cyclodextrin vesicles on various substrates.
- To characterize the resulting supported CD layers and their host-guest binding capabilities.
Main Methods:
- Microcontact printing (muCP) for surface patterning.
- Contact angle goniometry, atomic force microscopy (AFM), and confocal fluorescence microscopy (CFM).
- Fluorescence recovery after photobleaching (FRAP) for fluidity assessment.
Main Results:
- CD vesicles preferentially adsorb on hydrophobic and cationic areas over hydrophilic ones.
- Formation of supported monolayers and bilayers of amphiphilic cyclodextrins.
- Demonstration of supramolecular host-guest interactions and patterned binding using fluorescent guests.
Conclusions:
- Supported CD layers serve as versatile supramolecular platforms.
- Patterned host-guest chemistry can be achieved on these platforms.
- Controlled adsorption of CD vesicles enables tailored surface functionalization.
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