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Updated: Jul 13, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation
Mohammad M Hosseini1, Hooman Yarmohammadi
1Department of Urology, Motahari Hospital, Jahrom University of Medical Sciences, Jahrom, Shiraz, Iran.
Introduction:
The aim of this study was to compare the efficacy of fluoxetine alone and combined with sildenafil in patients complaining of premature ejaculation.
Patients And Methods:
Ninety-one married potent men, 21-43 years old, with premature ejaculation but without any obvious organic cause were enrolled. Pretreatment evaluation included history, physical examination, and self-administration of the International Index of Erectile Function questionnaire. The patients were randomly divided into two groups: group A patients (n = 48) received 20 mg fluoxetine daily for 4 weeks and then 20 mg as needed 2-3 h before sexual activity for 4 months, and group B patients (n = 43) received group A regimen plus 50 mg sildenafil as needed 1 h before sexual activity for 4 months.
Results:
Ejaculatory latency time and intercourse satisfaction significantly improved in group B as compared with group A (p < 0.05).
Conclusion:
Fluoxetine combined with sildenafil seems to provide significantly better ejaculatory latency time and intercourse satisfaction as compared with fluoxetine alone in patients with premature ejaculation.
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