Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs for Treatment of Diarrhea-Predominant IBS

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

Hormonal Regulation of the Menstrual Cycle

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Drugs for Treatment of Ulcerative Colitis in IBD

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tau positron emission tomography imaging in C9orf72 repeat expansion carriers.

European journal of neurology·2019

Same author

Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis.

Acta psychiatrica Scandinavica·2014

Same author

Localization of mGluR5, GABAB, GABAA, and cannabinoid receptors on the vago-vagal reflex pathway responsible for transient lower esophageal sphincter relaxation in humans: an immunohistochemical study.

Neurogastroenterology and motility·2012

Same author

Grading quality of evidence and strength of recommendations in clinical practice guidelines part 3 of 3. The GRADE approach to developing recommendations.

Allergy·2011

Same author

The GABA(B) receptor agonist AZD9343 inhibits transient lower oesophageal sphincter relaxations and acid reflux in healthy volunteers: a phase I study.

Alimentary pharmacology & therapeutics·2009

Same author

Association of diabetes with age-related macular degeneration in the EUREYE study.

The British journal of ophthalmology·2009

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Published on: October 4, 2024

Danazol for heavy menstrual bleeding.

H Beaumont, C Augood, K Duckitt

The Cochrane Database of Systematic Reviews

|July 20, 2007

Summary

Danazol effectively reduces heavy menstrual bleeding (HMB) compared to other medical treatments. However, its use may be limited by side effects and the need for ongoing treatment, with small trial sizes impacting recommendations.

Area of Science:

Gynecology
Pharmacology

Background:

Heavy menstrual bleeding (HMB) significantly impacts premenopausal women's health.
Medical therapies are preferred over surgery for HMB, but treatment effectiveness varies.
Danazol, a synthetic steroid, induces endometrial atrophy, reducing menstrual loss.

Purpose of the Study:

To evaluate the effectiveness and tolerability of Danazol for treating heavy menstrual bleeding in women of reproductive age.

Main Methods:

Systematic review of randomized controlled trials (RCTs) comparing Danazol to placebo or other medical treatments for HMB.
Searched multiple databases including Cochrane, MEDLINE, EMBASE, and CINAHL up to April 2007.
Nine RCTs involving 353 women were included, with data extraction and quality assessment by two independent reviewers.

Related Experiment Videos

Last Updated: Jul 13, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Published on: October 4, 2024

Main Results:

Danazol demonstrated greater efficacy than placebo, progestogens, NSAIDs, and OCPs in reducing menstrual blood loss (MBL), though confidence intervals were wide.
Danazol treatment resulted in more adverse events compared to NSAIDs and progestogens.
Danazol significantly reduced the duration of menses compared to NSAIDs and progesterone-releasing IUDs.

Conclusions:

Danazol appears effective for HMB but may be limited by side effects and the need for continuous treatment.
Small trial sizes and limited data restrict definitive clinical recommendations.
Further research on Danazol for HMB is unlikely, and this review is unlikely to be updated.