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Related Experiment Video

Updated: Jul 13, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

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Published on: May 16, 2025

WITHDRAWN: Rice-based oral rehydration solution for treating diarrhoea.

O Fontaine¹, S M Gore, N F Pierce

¹World Health Organization, Division of Child Health and Development, Via Appia, 1211 - Geneva -27, Switzerland. fontaineo@who.ch

The Cochrane Database of Systematic Reviews

|July 20, 2007

Summary

Rice-based oral rehydration salts solution significantly reduced stool output in cholera patients. However, this benefit was not observed in infants and children with non-cholera diarrhea.

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Area of Science:

Gastroenterology
Infectious Diseases
Public Health

Background:

Oral rehydration therapy (ORT) is a standard treatment for dehydration caused by diarrhea.
Current glucose-based ORT solutions do not reduce stool loss or illness duration.
Improved ORT could reduce ineffective treatments and improve diarrhea-related morbidity and mortality.

Purpose of the Study:

To evaluate the efficacy of rice-based oral rehydration salts (ORS) compared to glucose-based ORS.
To assess the impact on stool output and diarrhea duration in acute watery diarrhea patients.

Main Methods:

Systematic review and meta-analysis of 22 randomized controlled trials.
Compared standard WHO ORS with rice-based ORS (50-80g/L rice powder replacing glucose).
Independent data extraction by a statistician and clinician.

Main Results:

Rice-based ORS significantly reduced stool output in cholera patients (children and adults) within 24 hours.
Mean stool output reduction: 67 mL/kg (children) and 51 mL/kg (adults) in cholera.
Minimal reduction in stool loss (4 mL/kg) observed in infants and children with non-cholera diarrhea.

Conclusions:

Rice-based ORS demonstrates effectiveness in reducing stool output for cholera patients.
The stool-reducing effect of rice-based ORS was not evident in non-cholera diarrhea cases.
Further research may explore specific applications for rice-based ORS in different diarrheal conditions.