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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Irritable bowel syndrome and bloating.
1Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48170, USA. whasler@umich.edu
Best Practice & Research. Clinical Gastroenterology
|July 24, 2007
Summary
Irritable bowel syndrome (IBS) gaseous symptoms like bloating stem from gas issues or abdominal muscle dysfunction. Effective IBS treatment targets these specific causes with tailored therapies for symptom relief.
Area of Science:
- Gastroenterology
- Digestive Health
- Irritable Bowel Syndrome (IBS) Pathophysiology
Background:
- Gaseous symptoms, including bloating, eructation, and flatulence, are common in Irritable Bowel Syndrome (IBS).
- These symptoms arise from complex factors: excess gas production, altered gas transit, heightened visceral sensitivity, or abdominal wall muscle dysfunction.
- Recent research focuses on understanding the pathogenesis and developing novel therapies for IBS-related bloating.
Purpose of the Study:
- To review the underlying causes of gaseous symptoms in IBS patients.
- To outline diagnostic approaches for patients presenting with unexplained gas and bloating.
- To discuss current and emerging therapeutic strategies for managing IBS-related gaseous symptoms.
Main Methods:
- Literature review of recent investigations into IBS pathophysiology and treatment.
- Analysis of diagnostic criteria and functional testing for unexplained gas and bloating.
- Categorization of available therapeutic interventions based on their mechanism of action.
Main Results:
- Gaseous symptoms in IBS are multifactorial, involving gas dynamics, gut sensitivity, and somatic factors.
- Diagnosis requires excluding organic diseases and employing targeted functional testing.
- A range of treatments exist, from lifestyle changes to medications modulating gut function.
Conclusions:
- Effective management of IBS gaseous symptoms necessitates identifying and targeting specific pathophysiologic defects.
- Therapeutic options include dietary adjustments, enzyme use, gut flora modulation, and transit-altering drugs.
- Personalized treatment plans are crucial for addressing the diverse causes of bloating and gas in IBS.
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